FOXC1A
Gene Ontology Biological Process
- adrenal gland development [IGI]
- blood vessel development [IGI]
- camera-type eye development [IGI]
- closure of optic fissure [IMP]
- glomerular visceral epithelial cell fate commitment [IGI]
- pronephric glomerulus development [IGI]
- regulation of vascular permeability [IGI]
- somitogenesis [IMP]
- vasculature development [IGI, IMP]
NPHS2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Lmx1b and FoxC combinatorially regulate podocin expression in podocytes.
Podocin is a key protein of the kidney podocyte slit diaphragm protein complex, an important part of the glomerular filtration barrier. Mutations in the human podocin gene NPHS2 cause familial or sporadic forms of renal disease owing to the disruption of filtration barrier integrity. The exclusive expression of NPHS2 in podocytes reflects its unique function and raises interesting questions about ... [more]
Throughput
- Low Throughput
Additional Notes
- EMSA
Curated By
- BioGRID