BAIT

FES1

YBR101C
Hsp70 (Ssa1p) nucleotide exchange factor; required for the release of misfolded proteins from the Hsp70 system to the Ub-proteasome machinery for destruction; cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

BTN2

YGR142W
v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; contributes to prion curing; BTN2 has a paralog, CUR1, that arose from the whole genome duplication
Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Dynamics of DNA damage-induced nuclear inclusions are regulated by SUMOylation of Btn2.

Kumar A, Mathew V, Stirling PC

Spatial compartmentalization is a key facet of protein quality control that serves to store disassembled or non-native proteins until triage to the refolding or degradation machinery can occur in a regulated manner. Yeast cells sequester nuclear proteins at intranuclear quality control bodies (INQ) in response to various stresses, although the regulation of this process remains poorly understood. Here we reveal ... [more]

Nat Commun Apr. 13, 2024; 15(1);3215 [Pubmed: 38615096]

Throughput

  • Low Throughput

Ontology Terms

  • heat sensitivity (APO:0000147)

Additional Notes

  • genetic complex
  • the elevated levels of INQ in Btn2-6KR actually correlated with partial rescue of temperature sensitivity in fes1/hsp104

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
BTN2 FES1
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
3312270

Curated By

  • BioGRID