BAIT
CG2993
Dmel\CG2993, Dmel_CG2993
CG2993 gene product from transcript CG2993-RB
GO Process (1)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Drosophila melanogaster
PREY
VAV
BcDNA:GH01128, CG7893, Dmel\CG7893, DroVav, Dmel_CG7893
Vav ortholog (H. sapiens)
GO Process (15)
GO Function (3)
GO Component (0)
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IDA]
- actin filament organization [IMP]
- activation of Cdc42 GTPase activity [IDA]
- activation of Rac GTPase activity [IDA]
- axon guidance [IMP]
- axonogenesis [IMP]
- cell adhesion [IMP]
- cell migration [IMP]
- central nervous system development [IGI]
- dorsal closure [IMP]
- melanotic encapsulation of foreign target [IMP]
- myoblast fusion [IMP]
- open tracheal system development [IMP]
- photoreceptor cell axon guidance [IMP]
- regulation of cell shape [IMP]
Gene Ontology Molecular Function
Drosophila melanogaster
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Comparative interactome analysis of ?-arrestin families in human and Drosophila.
The ?-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor (GPCR)-mediated and non-GPCR-mediated pathways, across eukaryotes. However, unlike ?-arrestins, only a few ?-arrestin targets and functions have been characterized. Here, using affinity purification and mass spectrometry, we constructed interactomes for 6 human and 12 Drosophila ?-arrestins. The resulting high-confidence interactomes comprised ... [more]
Elife Jan. 25, 2024; 12(); [Pubmed: 38270169]
Throughput
- High Throughput
Additional Notes
- Affinity capture MS was carried out to identify high confident protein interactors with a FDR of less than or equal to 0.01 and a minimum spectral count of 6
Curated By
- BioGRID