BAIT
ARRDC2
CLONE24945, PP2703
arrestin domain containing 2
GO Process (0)
GO Function (0)
GO Component (2)
Gene Ontology Cellular Component
Homo sapiens
PREY
FARP2
FIR, FRG, PLEKHC3
FERM, RhoGEF and pleckstrin domain protein 2
GO Process (11)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- Rac protein signal transduction [IDA]
- actin cytoskeleton reorganization [ISS]
- axon guidance [TAS]
- cell adhesion [ISS]
- neuron remodeling [IDA]
- osteoclast differentiation [ISS]
- podosome assembly [ISS]
- positive regulation of Rac GTPase activity [ISS]
- positive regulation of Rho GTPase activity [IDA]
- regulation of integrin activation [ISS]
- semaphorin-plexin signaling pathway [ISS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Comparative interactome analysis of ?-arrestin families in human and Drosophila.
The ?-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor (GPCR)-mediated and non-GPCR-mediated pathways, across eukaryotes. However, unlike ?-arrestins, only a few ?-arrestin targets and functions have been characterized. Here, using affinity purification and mass spectrometry, we constructed interactomes for 6 human and 12 Drosophila ?-arrestins. The resulting high-confidence interactomes comprised ... [more]
Elife Jan. 25, 2024; 12(); [Pubmed: 38270169]
Throughput
- High Throughput
Additional Notes
- Affinity capture MS was carried out to identify high confident protein interactors with a FDR of less than or equal to 0.01 and a minimum spectral count of 6
Curated By
- BioGRID