BAIT
ARRDC3
TLIMP
arrestin domain containing 3
GO Process (1)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SMAD5
DWFC, JV5-1, MADH5
SMAD family member 5
GO Process (8)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- BMP signaling pathway [ISS, TAS]
- cellular response to BMP stimulus [ISS]
- embryonic pattern specification [ISS]
- intracellular signal transduction [NAS, TAS]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [ISS]
- positive regulation of transcription, DNA-templated [NAS]
- signal transduction [NAS]
- transforming growth factor beta receptor signaling pathway [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Comparative interactome analysis of ?-arrestin families in human and Drosophila.
The ?-arrestins form a large family of evolutionally conserved modulators that control diverse signaling pathways, including both G-protein-coupled receptor (GPCR)-mediated and non-GPCR-mediated pathways, across eukaryotes. However, unlike ?-arrestins, only a few ?-arrestin targets and functions have been characterized. Here, using affinity purification and mass spectrometry, we constructed interactomes for 6 human and 12 Drosophila ?-arrestins. The resulting high-confidence interactomes comprised ... [more]
Elife Jan. 25, 2024; 12(); [Pubmed: 38270169]
Throughput
- High Throughput
Additional Notes
- Affinity capture MS was carried out to identify high confident protein interactors with a FDR of less than or equal to 0.01 and a minimum spectral count of 6
Curated By
- BioGRID