BAIT
PLK-1
CELE_C14B9.4
Protein PLK-1
GO Process (15)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- apoptotic process [IMP]
- centrosome cycle [IMP]
- embryo development ending in birth or egg hatching [IMP]
- female meiosis II [IMP]
- hermaphrodite genitalia development [IMP]
- meiotic chromosome segregation [IMP]
- meiotic nuclear division [IMP]
- mitotic nuclear division [IMP]
- mitotic nuclear envelope disassembly [IMP, TAS]
- mitotic spindle organization [IMP]
- nematode larval development [IMP]
- oogenesis [IMP]
- polar body extrusion after meiotic divisions [IMP]
- regulation of cell cycle [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Caenorhabditis elegans
PREY
NPP-12
CELE_T23H2.1, T23H2.1
npp-12 encodes Gp210, an evolutionarily conserved membrane protein of the nuclear pore complex (NPC); NPP-12 is required for embryonic viability and normal nuclear membrane structures.
GO Process (2)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Caenorhabditis elegans
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos.
The nuclear envelope, which protects and organizes the genome, is dismantled during mitosis. In the Caenorhabditis elegans zygote, nuclear envelope breakdown (NEBD) of the parental pronuclei is spatially and temporally regulated during mitosis to promote the unification of the maternal and paternal genomes. Nuclear pore complex (NPC) disassembly is a decisive step of NEBD, essential for nuclear permeabilization. By combining ... [more]
Sci Adv Jul. 21, 2023; 9(29);eadf7826 [Pubmed: 37467327]
Throughput
- Low Throughput
Curated By
- BioGRID