PTPN5
Gene Ontology Biological Process
Gene Ontology Molecular Function
FYN
Gene Ontology Biological Process
- T cell activation [IBA]
- T cell receptor signaling pathway [IBA, ISO]
- activated T cell proliferation [ISO]
- cell differentiation [IBA]
- cell migration [IBA]
- cell surface receptor signaling pathway [ISO]
- cellular response to growth factor stimulus [IEP]
- cellular response to peptide hormone stimulus [IEP]
- cellular response to platelet-derived growth factor stimulus [ISO]
- cellular response to transforming growth factor beta stimulus [ISO]
- central nervous system development [IBA]
- dendrite morphogenesis [ISO]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- forebrain development [ISO]
- innate immune response [IBA]
- ionotropic glutamate receptor signaling pathway [TAS]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IMP]
- negative regulation of gene expression [ISO]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of protein catabolic process [ISO]
- neuron migration [ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, IMP, ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein localization to nucleus [ISO]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [ISO]
- regulation of cell proliferation [IBA]
- regulation of cell shape [ISO]
- response to drug [IEP]
- response to ethanol [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function- CD4 receptor binding [IPI]
- CD8 receptor binding [IPI]
- G-protein coupled receptor binding [ISO]
- T cell receptor binding [IDA]
- ephrin receptor binding [ISO]
- glycoprotein binding [IPI, ISO]
- growth factor receptor binding [ISO]
- ion channel binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase activity [IDA, ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI]
- tubulin binding [ISO]
- CD4 receptor binding [IPI]
- CD8 receptor binding [IPI]
- G-protein coupled receptor binding [ISO]
- T cell receptor binding [IDA]
- ephrin receptor binding [ISO]
- glycoprotein binding [IPI, ISO]
- growth factor receptor binding [ISO]
- ion channel binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- peptide hormone receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [IDA]
- protein binding [IPI]
- protein complex binding [IPI]
- protein kinase activity [IDA, ISO]
- protein tyrosine kinase activity [IDA, ISO]
- receptor binding [IPI]
- tubulin binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Striatal-enriched protein tyrosine phosphatase regulates the PTP?/Fyn signaling pathway.
The tyrosine kinase Fyn has two regulatory tyrosine residues that when phosphorylated either activate (Tyr(420)) or inhibit (Tyr(531)) Fyn activity. Within the central nervous system, two protein tyrosine phosphatases (PTPs) target these regulatory tyrosines in Fyn. PTP? dephosphorylates Tyr(531) and activates Fyn, while STEP (STriatal-Enriched protein tyrosine Phosphatase) dephosphorylates Tyr(420) and inactivates Fyn. Thus, PTP? and STEP have opposing functions ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTPN5 FYN | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID