BAIT

HECTD1

EULIR
HECT domain containing E3 ubiquitin protein ligase 1
UPS Project
GO Process (1)
GO Function (2)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

CT45A2

CT45-2, CT45.2
cancer/testis antigen family 45, member A2
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

Vaughan N, Scholz N, Lindon C, Licchesi JDF

The cell cycle is tightly regulated by protein phosphorylation and ubiquitylation events. During mitosis, the multi-subunit cullin-RING E3 ubiquitin ligase APC/c functions as a molecular switch which signals for one cell to divide into two daughter cells, through the ubiquitylation and proteasomal degradation of mitotic cyclins. The contributions of other E3 ligase families during cell cycle progression remain less well ... [more]

Sci Rep Dec. 01, 2021; 12(1);13160 [Pubmed: 35915203]

Throughput

  • High Throughput

Curated By

  • BioGRID