Publication

Interactome and Ubiquitinome Analyses Identify Functional Targets of Herpes Simplex Virus 1 Infected Cell Protein 0.

Hou F, Sun Z, Deng Y, Chen S, Yang X, Ji F, Zhou M, Ren K, Pan D

Herpes simplex virus 1 (HSV-1) can productively infect multiple cell types and establish latent infection in neurons. Infected cell protein 0 (ICP0) is an HSV-1 E3 ubiquitin ligase crucial for productive infection and reactivation from latency. However, our knowledge about its targets especially in neuronal cells is limited. We confirmed that, like in non-neuronal cells, ICP0-null virus exhibited major replication ... [more]

Throughput

• High Throughput

Additional Notes

• Affinity capture MS was carried out in N2A cells to identify high confident protein-protein interactors with a fold change greater than or equal to 1.2 over controls and p < 0.05

Curated By

• BioGRID