PIM1
Gene Ontology Biological Process
- cellular response to oxidative stress [IBA]
- chaperone-mediated protein complex assembly [IGI]
- misfolded or incompletely synthesized protein catabolic process [IGI, IMP]
- mitochondrion organization [IBA]
- oxidation-dependent protein catabolic process [IBA]
- protein homooligomerization [IBA]
- response to hypoxia [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MDH1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress.
Mitochondria consist of hundreds of proteins, most of which are inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions remains poorly understood. Here, we show that mitochondria form spatially defined protein aggregates as a stress-protecting mechanism. Two different types of intramitochondrial protein aggregates can be distinguished. The mitoribosomal protein Var1 ... [more]
Throughput
- High Throughput
Additional Notes
- pull down with Pim1S1015A mutant in an HSP78 deletion mutant
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MDH1 PIM1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - | |
| MDH1 PIM1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 2 | BioGRID | 3618010 | |
| MDH1 PIM1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -2.5439 | BioGRID | 578250 |
Curated By
- BioGRID