BAIT

LST-3

CELE_Y37A1B.1
Protein LST-3
GO Process (3)
GO Function (0)
GO Component (0)

Gene Ontology Biological Process

Caenorhabditis elegans
PREY

APY-1

CELE_F08C6.6, F08C6.6
apy-1 encodes a membrane-bound uridine diphosphatase (UDPase, endo-apyrase) orthologous to human CANT1 and paralogous to ZK563.7; APY-1 is required for repression of the unfolded protein response of stressed endoplasmic reticulum (ER), for normally organized pharynx and thin muscle fibers in adults, and for normally high fertility, rapid growth, and long lifespan; apy-1 is transcriptionally activated by tunicamycin, 6% EtOH, or excess heat (25 degrees C), each of which stresses the ER, and this activation requires both ATF-6 and IRE-1; APY-1 can hydrolyze either UDP or GDP, but has more activity with UDP.
Caenorhabditis elegans

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing.

Lugano DI, Barrett LN, Chaput D, Park MA, Westerheide SD

The Cell Division Cycle and Apoptosis Regulator (CCAR) protein family members have recently emerged as regulators of alternative splicing and transcription, as well as having other key physiological functions. For example, mammalian CCAR2/DBC1 forms a complex with the zinc factor protein ZNF326 to integrate alternative splicing with RNA polymerase II transcriptional elongation in AT-rich regions of the DNA. Additionally, Caenorhabditis ... [more]

RNA Biol Jan. 01, 2024; 21(1);1-11 [Pubmed: 38126797]

Throughput

  • High Throughput

Curated By

  • BioGRID