BAIT

PAQR-2

CELE_Y32H12A.5, Y32H12A.5
Progestin and AdipoQ Receptor family
GO Process (2)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Caenorhabditis elegans
PREY

ALDO-1

CELE_T05D4.1, T05D4.1
aldo-1 is orthologous to the human gene ALDOLASE A, FRUCTOSE-BISPHOSPHATE (ALDOA; OMIM:103850), which when mutated leads to aldolase A deficiency.
GO Process (2)
GO Function (2)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Caenorhabditis elegans

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity.

Ruiz M, Devkota R, Kaper D, Ruhanen H, Busayavalasa K, Radovic U, Henricsson M, Kaekelae R, Boren J, Pilon M

The human AdipoR2 and its Caenorhabditis elegans homolog PAQR-2 are multipass plasma membrane proteins that protect cells against membrane rigidification. However, how AdipoR2 promotes membrane fluidity mechanistically is not clear. Using 13C-labeled fatty acids, we show that AdipoR2 can promote the elongation and incorporation of membrane-fluidizing polyunsaturated fatty acids into phospholipids. To elucidate the molecular basis of these activities, we ... [more]

J Biol Chem Jun. 01, 2023; 299(6);104799 [Pubmed: 37164154]

Throughput

  • High Throughput

Curated By

  • BioGRID