BAIT
SIN-3
CELE_F02E9.4
Protein SIN-3
GO Process (8)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Caenorhabditis elegans
PREY
TLK-1
CELE_C07A9.3
Protein TLK-1
GO Process (8)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- embryo development ending in birth or egg hatching [IMP]
- positive regulation of multicellular organism growth [IMP]
- positive regulation of protein kinase activity [IDA]
- protein autophosphorylation [IDA]
- protein methylation [IMP]
- protein phosphorylation [IDA]
- regulation of transcription from RNA polymerase II promoter [IMP]
- reproduction [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Caenorhabditis elegans
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans.
The transcriptional co-regulator SIN3 influences gene expression through multiple interactions that include histone deacetylases. Haploinsufficiency and mutations in SIN3 are the underlying cause of Witteveen-Kolk syndrome and related intellectual disability and autism syndromes, emphasizing its key role in development. However, little is known about the diversity of its interactions and functions in developmental processes. Here, we show that loss of ... [more]
Development Nov. 01, 2023; 150(21); [Pubmed: 37818613]
Throughput
- High Throughput
Curated By
- BioGRID