BAIT
USP4
UNP, Unph
ubiquitin specific peptidase 4 (proto-oncogene)
GO Process (7)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- negative regulation of protein ubiquitination [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA, IMP]
- protein localization to cell surface [IDA]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of protein stability [IDA]
- spliceosomal tri-snRNP complex assembly [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
EVPL
EVPK
envoplakin
GO Process (3)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.
Ubiquitin-specific protease 4 (USP4) is highly overexpressed in colon cancer and acts as a potent protooncogenic protein by deubiquitinating ?-catenin. However, its prominent roles in tumor formation and migration in cancer cells are not fully understood by its deubiquitinating enzyme (DUB) activity on ?-catenin. Thus, we investigated an additional role of USP4 in cancer. In this study, we identified cortactin ... [more]
FASEB J May. 01, 2023; 37(5);e22900 [Pubmed: 37039823]
Throughput
- High Throughput
Curated By
- BioGRID