BAIT
CEBPB
C/EBP-beta, IL6DBP, NF-IL6, TCF5, PP9092
CCAAT/enhancer binding protein (C/EBP), beta
GO Process (7)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [IDA]
Homo sapiens
PREY
ARHGAP4
C1, RGC1, RhoGAP4, SrGAP4, p115
Rho GTPase activating protein 4
GO Process (8)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- Rho protein signal transduction [TAS]
- apoptotic signaling pathway [TAS]
- cytoskeleton organization [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of apoptotic process [TAS]
- positive regulation of signal transduction [TAS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBP?.
CCAAT enhancer-binding protein beta (C/EBP?) is a pioneer transcription factor that specifies cell differentiation. C/EBP? is intrinsically unstructured, a molecular feature common to many proteins involved in signal processing and epigenetics. The structure of C/EBP? differs depending on alternative translation initiation and multiple post-translational modifications (PTM). Mutation of distinct PTM sites in C/EBP? alters protein interactions and cell differentiation, suggesting ... [more]
iScience Mar. 29, 2019; 13();351-370 [Pubmed: 30884312]
Throughput
- High Throughput
Additional Notes
- FDR cutoff of 5%
- IP-MS in SU-DHL1 cells
Curated By
- BioGRID