BAIT

CEBPB

C/EBP-beta, IL6DBP, NF-IL6, TCF5, PP9092

CCAAT/enhancer binding protein (C/EBP), beta

Cell Cycle - Senescence Project

GO Process (7)

GO Function (4)

GO Component (2)

Gene Ontology Biological Process

acute-phase response [TAS]

immune response [TAS]

inflammatory response [TAS]

positive regulation of fat cell differentiation [ISS]

regulation of transcription involved in cell fate commitment [ISS]

regulation of transcription, DNA-templated [IDA]

response to endoplasmic reticulum stress [IDA]

Gene Ontology Molecular Function

DNA binding [TAS]
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
protein binding [IPI]
sequence-specific DNA binding transcription factor activity [NAS]

Gene Ontology Cellular Component

nucleoplasm [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

PSMD13

HSPC027, Rpn9, S11, p40.5

proteasome (prosome, macropain) 26S subunit, non-ATPase, 13

GO Process (21)

GO Function (0)

GO Component (7)

Gene Ontology Biological Process

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]

G1/S transition of mitotic cell cycle [TAS]

RNA metabolic process [TAS]

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]

antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]

antigen processing and presentation of peptide antigen via MHC class I [TAS]

apoptotic process [TAS]

cellular nitrogen compound metabolic process [TAS]

gene expression [TAS]

mRNA metabolic process [TAS]

mitotic cell cycle [TAS]

negative regulation of apoptotic process [TAS]

negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

protein polyubiquitination [TAS]

regulation of apoptotic process [TAS]

regulation of cellular amino acid metabolic process [TAS]

regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

small molecule metabolic process [TAS]

viral process [TAS]

Gene Ontology Cellular Component

extracellular vesicular exosome [IDA]

nucleoplasm [TAS]

proteasome accessory complex [ISS]

proteasome complex [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBP?.

Dittmar G, Hernandez DP, Kowenz-Leutz E, Kirchner M, Kahlert G, Wesolowski R, Baum K, Knoblich M, Hofstaetter M, Muller A, Wolf J, Reimer U, Leutz A

CCAAT enhancer-binding protein beta (C/EBP?) is a pioneer transcription factor that specifies cell differentiation. C/EBP? is intrinsically unstructured, a molecular feature common to many proteins involved in signal processing and epigenetics. The structure of C/EBP? differs depending on alternative translation initiation and multiple post-translational modifications (PTM). Mutation of distinct PTM sites in C/EBP? alters protein interactions and cell differentiation, suggesting ... [more]

iScience Mar. 29, 2019; 13();351-370 [Pubmed: 30884312]

Throughput

High Throughput

Additional Notes

FDR cutoff of 5%
IP-MS in SU-DHL1 cells

Curated By

BioGRID