Publication

System-wide mapping of peptide-GPCR interactions in C. elegans.

Beets I, Zels S, Vandewyer E, Demeulemeester J, Caers J, Baytemur E, Courtney A, Golinelli L, Hasakiogullari I, Schafer WR, Vertes PE, Mirabeau O, Schoofs L

Neuropeptides and peptide hormones are ancient, widespread signaling molecules that underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly by binding to G protein-coupled receptors (GPCRs). However, the organization of the peptidergic network and roles of many peptides remain elusive, as our insight into peptide-receptor interactions is limited and many peptide GPCRs are still orphan receptors. Here ... [more]

Throughput

• High Throughput

Additional Notes

• high throughput peptide-GPCR interaction screen

Curated By

• BioGRID