BAIT
GNRR-6
CELE_F13D2.2, F13D2.2
human GoNadotropin-Releasing hormone Receptor (GnRHR) related
GO Process (2)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Caenorhabditis elegans
PREY
NLP-23
CELE_T24D8.4, T24D8.4
nlp-23 encodes three predicted neuropeptide-like proteins; in C. elegans, nlp-23 is part of the FRPamide neuropeptide family that also contains nlp-2 and nlp-22; nlp-23 is expressed in the tail and in dorsal and ventral hypodermis; as loss of nlp-23 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of the nlp-23-encoded peptides in development and/or behavior is not yet known.
GO Process (0)
GO Function (0)
GO Component (0)
Caenorhabditis elegans
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
System-wide mapping of peptide-GPCR interactions in C. elegans.
Neuropeptides and peptide hormones are ancient, widespread signaling molecules that underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly by binding to G protein-coupled receptors (GPCRs). However, the organization of the peptidergic network and roles of many peptides remain elusive, as our insight into peptide-receptor interactions is limited and many peptide GPCRs are still orphan receptors. Here ... [more]
Cell Rep Sep. 26, 2023; 42(9);113058 [Pubmed: 37656621]
Throughput
- High Throughput
Additional Notes
- high throughput peptide-GPCR interaction screen
Curated By
- BioGRID