BAIT
TKR-1
CELE_C38C10.1, C38C10.1
tkr-1 encodes a G protein-coupled receptor that is the C. elegans tachykinin-like neuropeptide receptor homolog; by homology, TKR-1 is predicted to function in modulation of excitatory neurotransmission; as loss of tkr-1 activity via RNAi results in moderate reduction of fat content, TKR-1 may play a specific role in regulating lipid metabolism; a tkr-1 reporter gene fusion is reportedly expressed in the socket cells of the deirid and post-deirid sensilla from the L2 larval stage through adulthood.
GO Process (1)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Caenorhabditis elegans
PREY
T07C12.15
CELE_T07C12.15
Protein T07C12.15
GO Process (0)
GO Function (0)
GO Component (0)
Caenorhabditis elegans
Protein-peptide
An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments.
Publication
System-wide mapping of peptide-GPCR interactions in C. elegans.
Neuropeptides and peptide hormones are ancient, widespread signaling molecules that underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly by binding to G protein-coupled receptors (GPCRs). However, the organization of the peptidergic network and roles of many peptides remain elusive, as our insight into peptide-receptor interactions is limited and many peptide GPCRs are still orphan receptors. Here ... [more]
Cell Rep Sep. 26, 2023; 42(9);113058 [Pubmed: 37656621]
Throughput
- High Throughput
Additional Notes
- high throughput peptide-GPCR interaction screen
Curated By
- BioGRID