CCDC6
Gene Ontology Molecular Function
APC
Gene Ontology Biological Process
- apoptotic process [TAS]
- canonical Wnt signaling pathway [IC, NAS]
- cell adhesion [NAS]
- cell cycle arrest [IDA]
- cell migration [IMP]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to DNA damage stimulus [IDA]
- mitotic cytokinesis [IMP]
- mitotic spindle assembly checkpoint [IMP]
- negative regulation of canonical Wnt signaling pathway [IGI]
- negative regulation of cell proliferation [IDA]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of microtubule depolymerization [IDA, IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of protein catabolic process [IC, IGI]
- positive regulation of pseudopodium assembly [IMP]
- protein complex assembly [IDA]
- regulation of attachment of spindle microtubules to kinetochore [IMP, NAS]
- regulation of microtubule-based process [IMP]
- tight junction assembly [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.
Tumor suppressor p53 (TP53) is frequently mutated in cancer, often resulting not only in loss of its tumor-suppressive function but also acquisition of dominant-negative and even oncogenic gain-of-function traits. While wild-type p53 levels are tightly regulated, mutants are typically stabilized in tumors, which is crucial for their oncogenic properties. Here, we systematically profiled the factors that regulate protein stability of ... [more]
Throughput
- High Throughput
Additional Notes
- BioID
- High confidence BioID interactions had a minimum unique mass spectral count of 2 and SAINT BFDR score =< 0.01
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CCDC6 APC | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9588 | BioGRID | 2250135 | |
| CCDC6 APC | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.7695 | BioGRID | 3033017 |
Curated By
- BioGRID