ACE2
Gene Ontology Biological Process
- angiotensin catabolic process in blood [IC]
- angiotensin maturation [TAS]
- angiotensin-mediated drinking behavior [IMP]
- cellular protein metabolic process [TAS]
- positive regulation of reactive oxygen species metabolic process [IC]
- receptor biosynthetic process [IMP]
- receptor-mediated virion attachment to host cell [IDA]
- regulation of cell proliferation [TAS]
- regulation of cytokine production [IC]
- regulation of inflammatory response [IC]
- regulation of systemic arterial blood pressure by renin-angiotensin [IC, IMP]
- regulation of vasoconstriction [IC]
- regulation of vasodilation [IC]
- response to virus [IDA, IMP]
- viral entry into host cell [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SHROOM2
Gene Ontology Biological Process
- actin filament bundle assembly [ISS]
- apical protein localization [ISS]
- brain development [ISS]
- camera-type eye development [ISS]
- camera-type eye morphogenesis [ISS]
- cell migration [ISS]
- cell morphogenesis [IDA, ISS]
- cellular pigment accumulation [ISS]
- ear development [ISS]
- establishment of melanosome localization [ISS]
- eye pigment granule organization [ISS]
- lens morphogenesis in camera-type eye [ISS]
- melanosome organization [ISS]
- sodium ion transmembrane transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
PDZ-Containing Proteins Targeted by the ACE2 Receptor.
Angiotensin-converting enzyme 2 (ACE2) is a main receptor for SARS-CoV-2 entry to the host cell. Indeed, the first step in viral entry is the binding of the viral trimeric spike (S) protein to ACE2. Abundantly present in human epithelial cells of many organs, ACE2 is also expressed in the human brain. ACE2 is a type I membrane protein with an ... [more]
Throughput
- Low Throughput
Additional Notes
- High throughput holdup assay screening the ACE2 PDZ-binding motif (PBM) agains the human PDZome.
Curated By
- BioGRID