GRIK3
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IDA]
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [IDA]
- glutamate receptor signaling pathway [IDA]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IDA, ISS]
- negative regulation of synaptic transmission, glutamatergic [ISS]
- regulation of membrane potential [IDA, ISS]
- synaptic transmission [TAS]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRIK3
Gene Ontology Biological Process
- G-protein coupled glutamate receptor signaling pathway [IDA]
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [IDA]
- glutamate receptor signaling pathway [IDA]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IDA, ISS]
- negative regulation of synaptic transmission, glutamatergic [ISS]
- regulation of membrane potential [IDA, ISS]
- synaptic transmission [TAS]
- synaptic transmission, glutamatergic [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Crystal structures of the glutamate receptor ion channel GluK3 and GluK5 amino-terminal domains.
Ionotropic glutamate receptors (iGluRs) mediate the majority of fast excitatory synaptic neurotransmission in the central nervous system. The selective assembly of iGluRs into AMPA, kainate, and N-methyl-d-aspartic acid (NMDA) receptor subtypes is regulated by their extracellular amino-terminal domains (ATDs). Kainate receptors are further classified into low-affinity receptor families (GluK1-GluK3) and high-affinity receptor families (GluK4-GluK5) based on their affinity for the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRIK3 GRIK3 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | Low | - | BioGRID | - | |
| GRIK3 GRIK3 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID