Biochemical Activity (Ubiquitination)

An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.

Ostendorff HP, Peirano RI, Peters MA, Schlueter A, Bossenz M, Scheffner M, Bach I

The interactions of distinct cofactor complexes with transcription factors are decisive determinants for the regulation of gene expression. Depending on the bound cofactor, transcription factors can have either repressing or transactivating activities. To allow a switch between these different states, regulated cofactor exchange has been proposed; however, little is known about the molecular mechanisms that are involved in this process. ... [more]

Nature Mar. 07, 2002; 416(6876);99-103 [Pubmed: 11882901]

Throughput

  • Low Throughput

Additional Notes

  • E2: UbcH5

Curated By

  • BioGRID