BAIT

FAM134C

family with sequence similarity 134, member C
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

RTN3

ASYIP, HAP, NSPL2, NSPLII, RTN3-A1
reticulon 3
Autophagy Project
GO Process (1)
GO Function (0)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum.

Gonzalez A, Covarrubias-Pinto A, Bhaskara RM, Glogger M, Kuncha SK, Xavier A, Seemann E, Misra M, Hoffmann ME, Braeuning B, Balakrishnan A, Qualmann B, Doetsch V, Schulman BA, Kessels MM, Huebner CA, Heilemann M, Hummer G, Dikic I

The endoplasmic reticulum (ER) undergoes continuous remodelling via a selective autophagy pathway, known as ER-phagy1. ER-phagy receptors have a central role in this process2, but the regulatory mechanism remains largely unknown. Here we report that ubiquitination of the ER-phagy receptor FAM134B within its reticulon homology domain (RHD) promotes receptor clustering and binding to lipidated LC3B, thereby stimulating ER-phagy. Molecular dynamics (MD) ... [more]

Nature Jun. 01, 2023; 618(7964);394-401 [Pubmed: 37225996]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
RTN3 FAM134C
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

High0.9996BioGRID
3160836

Curated By

  • BioGRID