BAIT

MEN1

MEAI, SCG2

multiple endocrine neoplasia I

GO Process (24)

GO Function (9)

GO Component (9)

Gene Ontology Biological Process

DNA repair [NAS]

MAPK cascade [IDA]

cellular response to DNA damage stimulus [IDA]

gene expression [TAS]

histone lysine methylation [IDA]

negative regulation of JNK cascade [IDA]

negative regulation of cell cycle [IDA]

negative regulation of cell proliferation [IDA]

negative regulation of cyclin-dependent protein serine/threonine kinase activity [IMP]

negative regulation of osteoblast differentiation [IGI]

negative regulation of protein phosphorylation [IDA]

negative regulation of sequence-specific DNA binding transcription factor activity [IDA]

negative regulation of telomerase activity [IMP]

negative regulation of transcription from RNA polymerase II promoter [IDA]

negative regulation of transcription, DNA-templated [IDA]

osteoblast development [IGI]

positive regulation of protein binding [IDA]

positive regulation of transcription from RNA polymerase II promoter [TAS]

positive regulation of transforming growth factor beta receptor signaling pathway [IMP]

response to UV [IDA]

response to gamma radiation [IDA]

transcription initiation from RNA polymerase II promoter [TAS]

transcription, DNA-templated [TAS]

transforming growth factor beta receptor signaling pathway [TAS]

Gene Ontology Molecular Function

R-SMAD binding [IPI]
Y-form DNA binding [IDA]
double-stranded DNA binding [IDA]
four-way junction DNA binding [IDA]
histone-lysine N-methyltransferase activity [IDA]
protein N-terminus binding [IPI]
protein binding [IPI]
protein binding, bridging [IDA]
transcription regulatory region DNA binding [IDA]

Gene Ontology Cellular Component

chromatin [IDA]

cleavage furrow [IDA]

cytoplasm [IDA]

histone methyltransferase complex [IDA, IPI]

nuclear matrix [IDA]

nucleoplasm [IDA, TAS]

protein complex [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

EIF3C

EIF3CL, EIF3S8, eIF3-p110

eukaryotic translation initiation factor 3, subunit C

GO Process (4)

GO Function (3)

GO Component (2)

Gene Ontology Biological Process

cellular protein metabolic process [TAS]

gene expression [TAS]

translation [TAS]

translational initiation [IC, IDA, TAS]

Gene Ontology Molecular Function

poly(A) RNA binding [IDA]
protein binding [IPI]
translation initiation factor activity [IC, IDA]

Gene Ontology Cellular Component

eukaryotic translation initiation factor 3 complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

Chou CW, Tan X, Hung CN, Lieberman B, Chen M, Kusi M, Mitsuya K, Lin CL, Morita M, Liu Z, Chen CL, Huang TH

The interplay between glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) is central to maintain energy homeostasis. It remains to be determined whether there is a mechanism governing metabolic fluxes based on substrate availability in microenvironments. Here we show that menin is a key transcription factor regulating the expression of OXPHOS and glycolytic genes in cancer cells and primary tumors with poor ... [more]

Cancers (Basel) Sep. 22, 2020; 12(9); [Pubmed: 32971831]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
MEN1 EIF3C	Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.	Salvati A (2022)	Low	-	BioGRID	-

Curated By

BioGRID