BAIT
KCTD13
1500003N18Rik, AV259508, PDIP1alpha, Pdip1, Poldip1
potassium channel tetramerisation domain containing 13
GO Process (7)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SPTBN4
1700022P15Rik, 5830426A08Rik, ROSA62, SpbIV, Spnb4, dyn, lnd, nmf261, nmf379, qv
spectrin beta, non-erythrocytic 4
GO Process (16)
GO Function (5)
GO Component (15)
Gene Ontology Biological Process
- adult behavior [IMP]
- adult walking behavior [IMP]
- axonogenesis [IMP]
- cardiac conduction [IMP]
- cellular protein localization [IMP]
- central nervous system projection neuron axonogenesis [IMP]
- clustering of voltage-gated sodium channels [IMP]
- establishment of protein localization to plasma membrane [IMP]
- fertilization [IMP]
- negative regulation of heart rate [IMP]
- positive regulation of multicellular organism growth [IMP]
- regulation of peptidyl-serine phosphorylation [IDA]
- regulation of sodium ion transport [IMP]
- reproductive process [IMP]
- sensory perception of sound [IMP]
- transmission of nerve impulse [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- PML body [ISO, ISS]
- adherens junction [IDA]
- axon [IDA]
- axon hillock [IDA]
- axon initial segment [IDA, ISO]
- cell body fiber [IDA]
- cytoplasm [ISO, ISS]
- extracellular vesicular exosome [ISO]
- membrane [ISO]
- neuronal cell body [IDA]
- node of Ranvier [IDA, ISO]
- nuclear matrix [ISO, ISS]
- paranode region of axon [IDA]
- plasma membrane [IDA]
- spectrin [ISO, ISS]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.
Temporal lobe epilepsy (TLE) is the most common and severe form of epilepsy in adults; however, its underlying pathomechanisms remain elusive. Dysregulation of ubiquitination is increasingly recognized to contribute to the development and maintenance of epilepsy. Herein, we observed for the first time that potassium channel tetramerization domain containing 13 (KCTD13) protein, a substrate-specific adapter for cullin3-based E3 ubiquitin ligase, ... [more]
Cell Death Differ Jul. 01, 2023; 30(7);1726-1741 [Pubmed: 37142655]
Throughput
- Low Throughput
Curated By
- BioGRID