BAIT
KCTD13
1500003N18Rik, AV259508, PDIP1alpha, Pdip1, Poldip1
potassium channel tetramerisation domain containing 13
GO Process (7)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SHROOM2
4832440C16, Apxl, C630003H05Rik, Shrm2, RP23-392C8.1
shroom family member 2
GO Process (15)
GO Function (5)
GO Component (13)
Gene Ontology Biological Process
- actin filament bundle assembly [IDA]
- apical protein localization [ISS]
- brain development [ISS]
- camera-type eye development [ISS]
- camera-type eye morphogenesis [ISS]
- cell migration [IMP]
- cell morphogenesis [IDA]
- cell-cell junction maintenance [IDA]
- cellular pigment accumulation [ISS]
- ear development [ISS]
- establishment of melanosome localization [ISS]
- eye pigment granule organization [ISS]
- lens morphogenesis in camera-type eye [ISS]
- melanosome organization [IMP]
- negative regulation of actin filament depolymerization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical junction complex [IDA]
- apical plasma membrane [IDA, ISS]
- cell cortex [IDA]
- cell-cell adherens junction [IDA]
- cell-cell junction [IDA]
- cortical actin cytoskeleton [IDA, ISO]
- cytoplasm [IDA]
- cytoskeleton [IDA]
- extracellular vesicular exosome [ISO]
- filamentous actin [IDA]
- neuronal cell body [IDA]
- plasma membrane [IDA]
- tight junction [IDA]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.
Temporal lobe epilepsy (TLE) is the most common and severe form of epilepsy in adults; however, its underlying pathomechanisms remain elusive. Dysregulation of ubiquitination is increasingly recognized to contribute to the development and maintenance of epilepsy. Herein, we observed for the first time that potassium channel tetramerization domain containing 13 (KCTD13) protein, a substrate-specific adapter for cullin3-based E3 ubiquitin ligase, ... [more]
Cell Death Differ Jul. 01, 2023; 30(7);1726-1741 [Pubmed: 37142655]
Throughput
- High Throughput
Curated By
- BioGRID