MUL1
Gene Ontology Biological Process
- activation of JUN kinase activity [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- cellular response to exogenous dsRNA [ISO]
- mitochondrial fission [ISO]
- mitochondrion localization [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of chemokine (C-C motif) ligand 5 production [ISO]
- negative regulation of defense response to virus by host [ISO]
- negative regulation of innate immune response [ISO]
- negative regulation of mitochondrial fusion [ISO]
- negative regulation of protein kinase B signaling [ISO]
- negative regulation of type I interferon-mediated signaling pathway [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of mitochondrial fission [ISO]
- positive regulation of protein sumoylation [ISO]
- protein stabilization [ISO]
- protein ubiquitination [ISO]
- regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MFN2
Gene Ontology Biological Process
- blastocyst formation [ISO]
- camera-type eye morphogenesis [ISO]
- cell cycle arrest [IDA]
- mitochondrial fusion [IMP, ISO, ISS]
- mitochondrial membrane organization [ISO, ISS]
- mitochondrion localization [ISO]
- negative regulation of Ras protein signal transduction [ISO]
- negative regulation of cell proliferation [IMP]
- negative regulation of smooth muscle cell proliferation [IDA]
- protein localization to pre-autophagosomal structure [ISO]
- protein targeting to mitochondrion [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ginsenoside compound K protects against cerebral ischemia/reperfusion injury via Mul1/Mfn2-mediated mitochondrial dynamics and bioenergy.
Ginsenoside compound K (CK), the main active metabolite in Panax ginseng, has shown good safety and bioavailability in clinical trials and exerts neuroprotective effects in cerebral ischemic stroke. However, its potential role in the prevention of cerebral ischemia/reperfusion (I/R) injury remains unclear. Our study aimed to investigate the molecular mechanism of ginsenoside CK against cerebral I/R injury.We used a combination ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MFN2 MUL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID