PRKAR2A
Gene Ontology Biological Process
- activation of phospholipase C activity [TAS]
- activation of protein kinase A activity [TAS]
- blood coagulation [TAS]
- cellular response to glucagon stimulus [TAS]
- energy reserve metabolic process [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- intracellular signal transduction [TAS]
- negative regulation of cAMP-dependent protein kinase activity [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of insulin secretion [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AKAP6
Gene Ontology Biological Process
- action potential [IC]
- cAMP-mediated signaling [NAS]
- cellular response to cAMP [IDA]
- cellular response to cytokine stimulus [ISS]
- intracellular signal transduction [IBA]
- negative regulation of cAMP biosynthetic process [ISS]
- positive regulation of NFAT protein import into nucleus [ISS]
- positive regulation of calcineurin-NFAT signaling cascade [ISS]
- positive regulation of cell growth [ISS]
- positive regulation of cell growth involved in cardiac muscle cell development [ISS]
- positive regulation of delayed rectifier potassium channel activity [IDA]
- positive regulation of potassium ion transmembrane transport [IDA]
- positive regulation of protein phosphatase type 2B activity [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [ISS]
- positive regulation of ryanodine-sensitive calcium-release channel activity [ISS]
- protein targeting [NAS]
- regulation of membrane repolarization [IDA]
- regulation of protein kinase A signaling [ISS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Chromodomain helicase binding protein 8 (Chd8) is a novel A-kinase anchoring protein expressed during rat cardiac development.
A-kinase anchoring proteins (AKAPs) bind the regulatory subunits of protein kinase A (PKA) and localize the holoenzyme to discrete signaling microdomains in multiple subcellular compartments. Despite emerging evidence for a nuclear pool of PKA that rapidly responds to activation of the PKA signaling cascade, only a few AKAPs have been identified that localize to the nucleus. Here we show a ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRKAR2A AKAP6 | Protein-peptide Protein-peptide An interaction is detected between a protein and a peptide derived from an interaction partner. This includes phage display experiments. | Low | - | BioGRID | - |
Curated By
- BioGRID