BAIT
USP7
2210010O09Rik, AA409944, AA617399, AU019296, AW548146, C80752, Hausp
ubiquitin specific peptidase 7
GO Process (12)
GO Function (9)
GO Component (3)
Gene Ontology Biological Process
- histone deubiquitination [IBA]
- maintenance of DNA methylation [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of apoptotic process [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA, ISO]
- proteolysis [IMP]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of protein stability [ISO]
- regulation of sequence-specific DNA binding transcription factor activity [ISO]
- regulation of transcription, DNA-templated [IBA]
- transcription-coupled nucleotide-excision repair [IBA, ISO]
Gene Ontology Molecular Function- cysteine-type endopeptidase activity [IMP, ISO]
- p53 binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin thiolesterase activity [IDA, ISO]
- ubiquitin-specific protease activity [IDA, ISO]
- cysteine-type endopeptidase activity [IMP, ISO]
- p53 binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin thiolesterase activity [IDA, ISO]
- ubiquitin-specific protease activity [IDA, ISO]
Mus musculus
PREY
VSTM2A
Vstm2, RP23-188C13.2
V-set and transmembrane domain containing 2A
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.
USP7, a ubiquitin-specific peptidase (USP), plays an important role in many cellular processes through its catalytic deubiquitination of various substrates. However, its nuclear function that shapes the transcriptional network in mouse embryonic stem cells (mESCs) remains poorly understood. We report that USP7 maintains mESC identity through both catalytic activity-dependent and -independent repression of lineage differentiation genes. Usp7 depletion attenuates SOX2 ... [more]
Sci Adv May. 19, 2023; 9(20);eade3888 [Pubmed: 37196079]
Throughput
- Low Throughput
Curated By
- BioGRID