PREY

BCL11B

9130430L19Rik, AI604821, B630002E05Rik, BCL-11B, Ctip2, Rit1
B cell leukemia/lymphoma 11B
Mus musculus

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

A network of genetic repression and derepression specifies projection fates in the developing neocortex.

Srinivasan K, Leone DP, Bateson RK, Dobreva G, Kohwi Y, Kohwi-Shigematsu T, Grosschedl R, McConnell SK

Neurons within each layer in the mammalian cortex have stereotypic projections. Four genes-Fezf2, Ctip2, Tbr1, and Satb2-regulate these projection identities. These genes also interact with each other, and it is unclear how these interactions shape the final projection identity. Here we show, by generating double mutants of Fezf2, Ctip2, and Satb2, that cortical neurons deploy a complex genetic switch that ... [more]

Proc Natl Acad Sci U S A Nov. 20, 2012; 109(47);19071-8 [Pubmed: 23144223]

Throughput

  • Low Throughput

Additional Notes

  • ChIP

Curated By

  • BioGRID