C1QBP
Gene Ontology Biological Process
- mature ribosome assembly [IMP, ISO]
- negative regulation of MDA-5 signaling pathway [ISO]
- negative regulation of RIG-I signaling pathway [ISO]
- negative regulation of defense response to virus [ISO]
- negative regulation of interferon-gamma production [ISO]
- negative regulation of interleukin-12 production [ISO]
- negative regulation of mRNA splicing, via spliceosome [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of dendritic cell chemotaxis [ISO]
- positive regulation of mitochondrial translation [IMP]
- positive regulation of neutrophil chemotaxis [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- positive regulation of trophoblast cell migration [ISO]
- regulation of complement activation [ISO]
Gene Ontology Molecular Function- adrenergic receptor binding [ISO]
- complement component C1q binding [ISO]
- hyaluronic acid binding [ISO]
- kininogen binding [ISO]
- mRNA binding [IDA]
- mitochondrial ribosome binding [IDA]
- protein binding [IPI]
- protein kinase C binding [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [ISO]
- adrenergic receptor binding [ISO]
- complement component C1q binding [ISO]
- hyaluronic acid binding [ISO]
- kininogen binding [ISO]
- mRNA binding [IDA]
- mitochondrial ribosome binding [IDA]
- protein binding [IPI]
- protein kinase C binding [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
C1QBP
Gene Ontology Biological Process
- mature ribosome assembly [IMP, ISO]
- negative regulation of MDA-5 signaling pathway [ISO]
- negative regulation of RIG-I signaling pathway [ISO]
- negative regulation of defense response to virus [ISO]
- negative regulation of interferon-gamma production [ISO]
- negative regulation of interleukin-12 production [ISO]
- negative regulation of mRNA splicing, via spliceosome [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of dendritic cell chemotaxis [ISO]
- positive regulation of mitochondrial translation [IMP]
- positive regulation of neutrophil chemotaxis [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- positive regulation of trophoblast cell migration [ISO]
- regulation of complement activation [ISO]
Gene Ontology Molecular Function- adrenergic receptor binding [ISO]
- complement component C1q binding [ISO]
- hyaluronic acid binding [ISO]
- kininogen binding [ISO]
- mRNA binding [IDA]
- mitochondrial ribosome binding [IDA]
- protein binding [IPI]
- protein kinase C binding [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [ISO]
- adrenergic receptor binding [ISO]
- complement component C1q binding [ISO]
- hyaluronic acid binding [ISO]
- kininogen binding [ISO]
- mRNA binding [IDA]
- mitochondrial ribosome binding [IDA]
- protein binding [IPI]
- protein kinase C binding [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
Cross-Linking-MS (XL-MS)
An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071).
Publication
The interactome of intact mitochondria by cross-linking mass spectrometry provides evidence for coexisting respiratory supercomplexes.
Mitochondria exert an immense amount of cytophysiological functions, but the structural basis of most of these processes is still poorly understood. Here we use cross-linking mass spectrometry to probe the organization of proteins in native mouse heart mitochondria. Our approach provides the largest survey of mitochondrial protein interactions reported so far. In total, we identify 3,322 unique residue-to-residue contacts involving ... [more]
Throughput
- High Throughput
Additional Notes
- Cross-linking of proteins from native mouse heart mitochondria was carried out using the lysine-reactive DSSO.
- High confidence interactions had an FDR =< 0.02 (2% false discovery rate).
Curated By
- BioGRID