STX4
Gene Ontology Biological Process
- SNARE complex assembly [ISO]
- intracellular protein transport [IBA]
- intracellular transport [NAS]
- long-term synaptic potentiation [ISO]
- membrane fusion [IDA]
- organelle fusion [ISO]
- positive regulation of catalytic activity [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of chemotaxis [ISO]
- positive regulation of eosinophil degranulation [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of immunoglobulin secretion [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- positive regulation of protein localization to cell surface [ISO]
- positive regulation of protein localization to plasma membrane [ISO]
- protein complex assembly [IDA]
- regulation of exocytosis [ISO]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- response to hydroperoxide [ISO]
- synaptic vesicle docking [IDA]
- synaptic vesicle fusion to presynaptic membrane [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- SNARE complex [IDA, ISO]
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA, ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- dendritic spine [ISO]
- endomembrane system [IBA]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IBA]
- intracellular [ISO]
- lamellipodium [ISO]
- lateral loop [ISO]
- membrane [ISO]
- myelin sheath adaxonal region [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- sarcolemma [IDA]
- somatodendritic compartment [ISO]
- specific granule [ISO]
- synapse [ISO]
- synaptic vesicle [IBA]
- trans-Golgi network [ISO]
STXBP1
Gene Ontology Biological Process
- axon target recognition [ISO]
- exocytosis [ISO]
- long term synaptic depression [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of synaptic transmission, GABAergic [ISO]
- neuromuscular synaptic transmission [ISO]
- neurotransmitter secretion [ISO]
- platelet aggregation [ISO]
- platelet degranulation [ISO]
- positive regulation of calcium ion-dependent exocytosis [ISO]
- positive regulation of exocytosis [IMP]
- protein localization to plasma membrane [ISO]
- protein stabilization [IDA]
- regulation of synaptic vesicle priming [IMP]
- synaptic vesicle maturation [ISO]
- vesicle docking involved in exocytosis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SNAP25/syntaxin4/VAMP2/Munc18-1 Complexes in Spinal Dorsal Horn Contributed to Inflammatory Pain.
Soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) have been implicated in the trafficking of postsynaptic glutamate receptors, including N-methyl-d-aspartate (NMDA)-subtype glutamate receptors (NMDARs) that are critical for nociceptive plasticity and behavioral sensitization. However, the components of SNAREs complex involved in spinal nociceptive processing remain largely unknown. Here we found that SNAP25, syntaxin4, VAMP2 and Munc18-1 were localized at postsynaptic sites ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STX4 STXBP1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID