BAIT
TIMP2
CSC-21K, DDC8, KIAA1731NL
TIMP metallopeptidase inhibitor 2
GO Process (3)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
C5
C5D, C5a, C5b, CPAMD4, ECLZB
complement component 5
GO Process (13)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- activation of MAPK activity [TAS]
- cell chemotaxis [TAS]
- cell surface receptor signaling pathway [TAS]
- chemotaxis [TAS]
- complement activation [TAS]
- inflammatory response [TAS]
- innate immune response [TAS]
- negative regulation of macrophage chemotaxis [IDA]
- positive regulation of chemokine secretion [IDA]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of complement activation [TAS]
- response to stress [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Mapping Extracellular Protein-Protein Interactions Using Extracellular Proximity Labeling (ePL).
Proximity labeling (PL) has given researchers the tools to explore protein-protein interactions (PPIs) in living systems; however, most PL studies are performed on intracellular targets. We have adapted the original PL method to investigate PPIs within the extracellular compartment, which we term extracellular PL (ePL). To demonstrate the utility of this modified technique, we investigated the interactome of the matrisome ... [more]
J Proteome Res Sep. 05, 2024; (); [Pubmed: 39238192]
Throughput
- High Throughput
Additional Notes
- BioID Extracellular Proximity Labeling (ePL)
- High confidence predominant proximal interactors for TIMP2 in HT1080 cells (Table S4).
Curated By
- BioGRID