BAIT

ESR1

ER, ESR, ESRA, ESTRR, Era, NR3A1, RP1-130E4.1
estrogen receptor 1
GO Process (22)
GO Function (16)
GO Component (6)
Homo sapiens
PREY

TFF1

BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2
trefoil factor 1
GO Process (3)
GO Function (1)
GO Component (0)

Gene Ontology Molecular Function

Homo sapiens

Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

The transcriptional co-repressor TLE3 suppresses basal signaling on a subset of estrogen receptor ? target genes.

Jangal M, Couture JP, Bianco S, Magnani L, Mohammed H, Gevry N

Chromatin constitutes a repressive barrier to the process of ligand-dependent transcriptional activity of nuclear receptors. Nucleosomes prevent the binding of estrogen receptor ? (ER?) in absence of ligand and thus represent an important level of transcriptional regulation. Here, we show that in breast cancer MCF-7 cells, TLE3, a co-repressor of the Groucho/Grg/TLE family, interacts with FoxA1 and is detected at ... [more]

Nucleic Acids Res Oct. 01, 2014; 42(18);11339-48 [Pubmed: 25223786]

Throughput

  • Low Throughput

Additional Notes

  • ChIP

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
ESR1 TFF1
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Low-BioGRID
657863

Curated By

  • BioGRID