BAIT
LMO4
A730077C12Rik, Crp3, Etohi4
LIM domain only 4
GO Process (11)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- negative regulation of protein complex assembly [IDA]
- neural tube closure [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of cell activation [IMP]
- regulation of cell fate specification [IMP]
- spinal cord association neuron differentiation [IGI]
- spinal cord motor neuron differentiation [IDA]
- thymus development [IGI]
- transcription from RNA polymerase II promoter [IDA]
- ventral spinal cord interneuron differentiation [IDA]
- ventricular septum development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
DEAF1
AU042387, C230009B13Rik, NUDR
deformed epidermal autoregulatory factor 1 (Drosophila)
GO Process (10)
GO Function (0)
GO Component (5)
Gene Ontology Biological Process
- behavioral fear response [IMP]
- embryonic skeletal system development [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of mammary gland epithelial cell proliferation [IMP, ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
- transcription from RNA polymerase II promoter [IDA]
- visual learning [IMP]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Contribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4.
The proteins LMO4 and DEAF1 contribute to the proliferation of mammary epithelial cells. During breast cancer LMO4 is upregulated, affecting its interaction with other protein partners. This may set cells on a path to tumour formation. LMO4 and DEAF1 interact, but it is unknown how they cooperate to regulate cell proliferation. In this study, we identify a specific LMO4-binding domain ... [more]
PLoS One Jun. 23, 2012; 7(6);e39218 [Pubmed: 22723967]
Throughput
- Low Throughput
Curated By
- BioGRID