BAIT

E

env, envelope, SARS-CoV2 E, E protein, emp, SARS-CoV-2 E, VEMP_SARS2, PRO_0000449651, GU280_gp04
Envelope small membrane protein
COVID-19 Coronavirus Project
GO Process (0)
GO Function (0)
GO Component (0)
Severe acute respiratory syndrome coronavirus 2
PREY

SLC4A4

HNBC1, KNBC, NBC1, NBC2, NBCe1-A, SLC4A5, hhNMC, pNBC
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

Pearson GJ, Mears HV, Broncel M, Snijders AP, Bauer DLV, Carlton JG

The ?-coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the global COVID-19 pandemic. Coronaviral Envelope (E) proteins are pentameric viroporins that play essential roles in assembly, release, and pathogenesis. We developed a nondisruptive tagging strategy for SARS-CoV-2 E and find that, at steady state, it localizes to the Golgi and to lysosomes. We identify sequences ... [more]

Sci Adv Apr. 05, 2024; 10(14);eadl5012 [Pubmed: 38569033]

Throughput

  • High Throughput

Additional Notes

  • TurboID

Curated By

  • BioGRID