PHB
Gene Ontology Biological Process
- DNA biosynthetic process [IMP]
- cellular response to interleukin-6 [ISO]
- histone deacetylation [ISO]
- negative regulation of androgen receptor signaling pathway [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of glucocorticoid receptor signaling pathway [ISO]
- negative regulation of transcription by competitive promoter binding [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of transcription, DNA-templated [ISO]
- osteoblast differentiation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- progesterone receptor signaling pathway [ISO]
- regulation of transcription, DNA-templated [ISO]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [ISO]
- extracellular vesicular exosome [ISO]
- extrinsic component of mitochondrial outer membrane [ISO]
- integral component of plasma membrane [ISO]
- membrane [ISO]
- mitochondrial crista [ISO]
- mitochondrial inner membrane [IDA]
- mitochondrion [IDA, ISO]
- myelin sheath [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
COQ3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- mitochondrion [IDA, ISO]
Cross-Linking-MS (XL-MS)
An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071).
Publication
Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.
Mitochondrial protein interactions and complexes facilitate mitochondrial function. These complexes range from simple dimers to the respirasome supercomplex consisting of oxidative phosphorylation complexes I, III, and IV. To improve understanding of mitochondrial function, we used chemical cross-linking mass spectrometry to identify 2,427 cross-linked peptide pairs from 327 mitochondrial proteins in whole, respiring murine mitochondria. In situ interactions were observed in ... [more]
Throughput
- High Throughput
Curated By
- BioGRID