ACAA2
Gene Ontology Biological Process
- acetyl-CoA metabolic process [ISO]
- cellular response to hypoxia [ISO]
- fatty acid beta-oxidation [ISO]
- negative regulation of mitochondrial membrane permeability involved in apoptotic process [ISO]
- negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NDUFA7
Gene Ontology Cellular Component
Cross-Linking-MS (XL-MS)
An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071).
Publication
Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.
Mitochondrial protein interactions and complexes facilitate mitochondrial function. These complexes range from simple dimers to the respirasome supercomplex consisting of oxidative phosphorylation complexes I, III, and IV. To improve understanding of mitochondrial function, we used chemical cross-linking mass spectrometry to identify 2,427 cross-linked peptide pairs from 327 mitochondrial proteins in whole, respiring murine mitochondria. In situ interactions were observed in ... [more]
Throughput
- High Throughput
Curated By
- BioGRID