An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle.

Song N, Deng L, Zeng L, He L, Liu C, Liu L, Fu R

Cell division cycle 123 (CDC123) has been implicated in a variety of human diseases. However, it remains unclear whether CDC123 plays a role in tumorigenesis and how its abundance is regulated. In this study, we found that CDC123 was highly expressed in breast cancer cells, and its high expression was positively correlated with a poor prognosis. Knowndown of CDC123 impaired ... [more]

Mol Carcinog Oct. 01, 2023; 62(10);1487-1503 [Pubmed: 37314216]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
HSPB1 CDC123	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Katsogiannou M (2014)	High	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

CDC123

Gene Ontology Biological Process

Gene Ontology Cellular Component

HSPB1

Gene Ontology Biological Process

Gene Ontology Molecular Function

identical protein binding [IPI]poly(A) RNA binding [IDA]protein binding [IPI]protein kinase C binding [ISS]protein kinase C inhibitor activity [ISS]protein kinase binding [IPI]ubiquitin binding [ISS]