BAIT

ACE2

ACEH, UNQ868/PRO1885
angiotensin I converting enzyme 2
Homo sapiens
PREY

ABI3BP

NESHBP, TARSH
ABI family, member 3 (NESH) binding protein
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication.

Montezano AC, Camargo LL, Mary S, Neves KB, Rios FJ, Stein R, Lopes RA, Beattie W, Thomson J, Herder V, Szemiel AM, McFarlane S, Palmarini M, Touyz RM

COVID-19, caused by SARS-CoV-2, is a respiratory disease associated with inflammation and endotheliitis. Mechanisms underling inflammatory processes are unclear, but angiotensin converting enzyme 2 (ACE2), the receptor which binds the spike protein of SARS-CoV-2 may be important. Here we investigated whether spike protein binding to ACE2 induces inflammation in endothelial cells and determined the role of ACE2 in this process. ... [more]

Sci Rep Aug. 28, 2023; 13(1);14086 [Pubmed: 37640791]

Throughput

  • High Throughput

Additional Notes

  • High confidence interactions were filtered with > 1 unique peptide and an FDR < 0.01.

Curated By

  • BioGRID