RNH203
Gene Ontology Biological Process
Gene Ontology Molecular Function
SMC6
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
The Smc5/6 complex counteracts R-loop formation at highly transcribed genes in cooperation with RNase H2.
The R-loop is a common transcriptional by-product that consists of an RNA-DNA duplex joined to a displaced strand of genomic DNA. While the effects of R-loops on health and disease are well established, there is still an incomplete understanding of the cellular processes responsible for their removal from eukaryotic genomes. Here, we show that a core regulator of chromosome architecture ... [more]
Throughput
- Low Throughput
Ontology Terms
- chromosome/plasmid maintenance (APO:0000143)
- vegetative growth (APO:0000106)
Additional Notes
- genetic complex
- simultaneous loss of Smc5/6 complex and RNase H activities results in severe growth defects in yeast
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SMC6 RNH203 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1239 | BioGRID | 2439552 |
Curated By
- BioGRID