BAIT
APOE
AD2, APO-E, LDLCQ5, LPG
apolipoprotein E
GO Process (68)
GO Function (14)
GO Component (19)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- N-methyl-D-aspartate receptor clustering [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IDA]
- cGMP-mediated signaling [IDA]
- cholesterol efflux [IDA]
- cholesterol homeostasis [IDA]
- cholesterol metabolic process [IDA, IMP]
- chylomicron remnant clearance [IMP]
- cytoskeleton organization [TAS]
- fatty acid homeostasis [IDA]
- high-density lipoprotein particle assembly [IDA]
- high-density lipoprotein particle clearance [IDA]
- high-density lipoprotein particle remodeling [IGI]
- intracellular transport [TAS]
- lipoprotein metabolic process [TAS]
- long-chain fatty acid transport [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of beta-amyloid formation [IDA]
- negative regulation of blood coagulation [IDA]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cholesterol biosynthetic process [IDA]
- negative regulation of cholesterol efflux [IDA]
- negative regulation of dendritic spine development [IDA]
- negative regulation of dendritic spine maintenance [IDA]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of inflammatory response [IC]
- negative regulation of lipid biosynthetic process [IDA]
- negative regulation of lipid transport across blood brain barrier [IDA]
- negative regulation of neuron death [IDA]
- negative regulation of phospholipid efflux [IDA]
- negative regulation of platelet activation [IDA]
- negative regulation of postsynaptic membrane organization [IDA]
- negative regulation of presynaptic membrane organization [IDA]
- nitric oxide mediated signal transduction [IDA]
- phospholipid efflux [IDA]
- phototransduction, visible light [TAS]
- positive regulation of beta-amyloid formation [IDA]
- positive regulation of cGMP biosynthetic process [IDA]
- positive regulation of cholesterol efflux [IDA, IGI]
- positive regulation of cholesterol esterification [IDA]
- positive regulation of dendritic spine development [IDA]
- positive regulation of dendritic spine maintenance [IDA]
- positive regulation of lipid biosynthetic process [IDA]
- positive regulation of lipid transport across blood brain barrier [IDA]
- positive regulation of low-density lipoprotein particle receptor catabolic process [IDA]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of neurofibrillary tangle assembly [IDA]
- positive regulation of neuron death [IDA]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phospholipid efflux [IDA]
- positive regulation of postsynaptic membrane organization [IDA]
- positive regulation of presynaptic membrane organization [IDA]
- protein import [IDA]
- receptor-mediated endocytosis [IDA]
- regulation of Cdc42 protein signal transduction [IDA]
- regulation of axon extension [TAS]
- regulation of beta-amyloid clearance [IDA]
- regulation of neuron death [IDA]
- regulation of neuronal synaptic plasticity [TAS]
- regulation of tau-protein kinase activity [IDA]
- response to reactive oxygen species [NAS]
- retinoid metabolic process [TAS]
- reverse cholesterol transport [IDA]
- small molecule metabolic process [TAS]
- synaptic transmission, cholinergic [TAS]
- triglyceride metabolic process [IDA, IMP]
- very-low-density lipoprotein particle clearance [IDA, IMP]
- very-low-density lipoprotein particle remodeling [IDA, IGI]
Gene Ontology Molecular Function- antioxidant activity [IDA]
- beta-amyloid binding [IDA]
- heparin binding [IDA]
- identical protein binding [IDA]
- lipid binding [IDA]
- lipid transporter activity [IDA]
- low-density lipoprotein particle receptor binding [IDA, IPI]
- metal chelating activity [IDA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- tau protein binding [IPI]
- very-low-density lipoprotein particle receptor binding [IDA, IPI]
- antioxidant activity [IDA]
- beta-amyloid binding [IDA]
- heparin binding [IDA]
- identical protein binding [IDA]
- lipid binding [IDA]
- lipid transporter activity [IDA]
- low-density lipoprotein particle receptor binding [IDA, IPI]
- metal chelating activity [IDA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- tau protein binding [IPI]
- very-low-density lipoprotein particle receptor binding [IDA, IPI]
Gene Ontology Cellular Component
- blood microparticle [IDA]
- chylomicron [IDA]
- cytoplasm [NAS, TAS]
- dendrite [NAS]
- early endosome [TAS]
- endocytic vesicle lumen [TAS]
- extracellular matrix [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- high-density lipoprotein particle [IDA]
- intermediate-density lipoprotein particle [IDA]
- low-density lipoprotein particle [IDA]
- membrane [IDA]
- neuronal cell body [NAS]
- nucleus [IDA]
- plasma membrane [TAS]
- very-low-density lipoprotein particle [IDA]
- vesicle [IDA]
Homo sapiens
PREY
APOE
AD2, APO-E, LDLCQ5, LPG
apolipoprotein E
GO Process (68)
GO Function (14)
GO Component (19)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- N-methyl-D-aspartate receptor clustering [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IDA]
- cGMP-mediated signaling [IDA]
- cholesterol efflux [IDA]
- cholesterol homeostasis [IDA]
- cholesterol metabolic process [IDA, IMP]
- chylomicron remnant clearance [IMP]
- cytoskeleton organization [TAS]
- fatty acid homeostasis [IDA]
- high-density lipoprotein particle assembly [IDA]
- high-density lipoprotein particle clearance [IDA]
- high-density lipoprotein particle remodeling [IGI]
- intracellular transport [TAS]
- lipoprotein metabolic process [TAS]
- long-chain fatty acid transport [IDA]
- negative regulation of MAP kinase activity [IDA]
- negative regulation of beta-amyloid formation [IDA]
- negative regulation of blood coagulation [IDA]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cholesterol biosynthetic process [IDA]
- negative regulation of cholesterol efflux [IDA]
- negative regulation of dendritic spine development [IDA]
- negative regulation of dendritic spine maintenance [IDA]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of inflammatory response [IC]
- negative regulation of lipid biosynthetic process [IDA]
- negative regulation of lipid transport across blood brain barrier [IDA]
- negative regulation of neuron death [IDA]
- negative regulation of phospholipid efflux [IDA]
- negative regulation of platelet activation [IDA]
- negative regulation of postsynaptic membrane organization [IDA]
- negative regulation of presynaptic membrane organization [IDA]
- nitric oxide mediated signal transduction [IDA]
- phospholipid efflux [IDA]
- phototransduction, visible light [TAS]
- positive regulation of beta-amyloid formation [IDA]
- positive regulation of cGMP biosynthetic process [IDA]
- positive regulation of cholesterol efflux [IDA, IGI]
- positive regulation of cholesterol esterification [IDA]
- positive regulation of dendritic spine development [IDA]
- positive regulation of dendritic spine maintenance [IDA]
- positive regulation of lipid biosynthetic process [IDA]
- positive regulation of lipid transport across blood brain barrier [IDA]
- positive regulation of low-density lipoprotein particle receptor catabolic process [IDA]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of neurofibrillary tangle assembly [IDA]
- positive regulation of neuron death [IDA]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phospholipid efflux [IDA]
- positive regulation of postsynaptic membrane organization [IDA]
- positive regulation of presynaptic membrane organization [IDA]
- protein import [IDA]
- receptor-mediated endocytosis [IDA]
- regulation of Cdc42 protein signal transduction [IDA]
- regulation of axon extension [TAS]
- regulation of beta-amyloid clearance [IDA]
- regulation of neuron death [IDA]
- regulation of neuronal synaptic plasticity [TAS]
- regulation of tau-protein kinase activity [IDA]
- response to reactive oxygen species [NAS]
- retinoid metabolic process [TAS]
- reverse cholesterol transport [IDA]
- small molecule metabolic process [TAS]
- synaptic transmission, cholinergic [TAS]
- triglyceride metabolic process [IDA, IMP]
- very-low-density lipoprotein particle clearance [IDA, IMP]
- very-low-density lipoprotein particle remodeling [IDA, IGI]
Gene Ontology Molecular Function- antioxidant activity [IDA]
- beta-amyloid binding [IDA]
- heparin binding [IDA]
- identical protein binding [IDA]
- lipid binding [IDA]
- lipid transporter activity [IDA]
- low-density lipoprotein particle receptor binding [IDA, IPI]
- metal chelating activity [IDA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- tau protein binding [IPI]
- very-low-density lipoprotein particle receptor binding [IDA, IPI]
- antioxidant activity [IDA]
- beta-amyloid binding [IDA]
- heparin binding [IDA]
- identical protein binding [IDA]
- lipid binding [IDA]
- lipid transporter activity [IDA]
- low-density lipoprotein particle receptor binding [IDA, IPI]
- metal chelating activity [IDA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- tau protein binding [IPI]
- very-low-density lipoprotein particle receptor binding [IDA, IPI]
Gene Ontology Cellular Component
- blood microparticle [IDA]
- chylomicron [IDA]
- cytoplasm [NAS, TAS]
- dendrite [NAS]
- early endosome [TAS]
- endocytic vesicle lumen [TAS]
- extracellular matrix [IDA]
- extracellular region [TAS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- high-density lipoprotein particle [IDA]
- intermediate-density lipoprotein particle [IDA]
- low-density lipoprotein particle [IDA]
- membrane [IDA]
- neuronal cell body [NAS]
- nucleus [IDA]
- plasma membrane [TAS]
- very-low-density lipoprotein particle [IDA]
- vesicle [IDA]
Homo sapiens
Cross-Linking-MS (XL-MS)
An interaction is detected between two proteins using chemically reactive or photo-activatable cross-linking reagents that covalently link amino acids in close proximity, followed by mass spectrometry analysis to identify the linked peptides (reviewed in PMID 37406423, 37104977). Experiments may be carried with live cells or cell lysates in which all proteins are expressed at endogenous levels (e.g. PMID 34349018, 35235311) or with recombinant proteins (e.g., PMID 28537071).
Publication
Probing Protein Structural Changes in Alzheimer's Disease via Quantitative Cross-linking Mass Spectrometry.
Alzheimer's disease (AD) is a progressive neurological disorder featuring abnormal protein aggregation in the brain, including the pathological hallmarks of amyloid plaques and hyperphosphorylated tau. Despite extensive research efforts, understanding the molecular intricacies driving AD development remains a formidable challenge. This study focuses on identifying key protein conformational changes associated with the progression of AD. To achieve this, we employed ... [more]
Anal Chem May. 14, 2024; 96(19);7506-7515 [Pubmed: 38690851]
Throughput
- Low Throughput
Additional Notes
- High confidence protein interaction in Alzheimer's Disease cerebrospinal fluid (CSF)
Related interactions
Curated By
- BioGRID