BAIT
SPOP
AI315626, Pcif1, TEF2, RP23-67E18.3
speckle-type POZ protein
GO Process (7)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- glucose homeostasis [IGI]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IGI]
- positive regulation of type B pancreatic cell apoptotic process [IGI]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IGI, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MYH7
B-MHC, MyHC-I, Myhc-b, Myhcb, beta-MHC, RP23-171A13.1
myosin, heavy polypeptide 7, cardiac muscle, beta
GO Process (9)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- adult heart development [ISO]
- muscle contraction [ISO]
- muscle filament sliding [ISO]
- regulation of heart rate [ISO]
- regulation of the force of heart contraction [ISO]
- striated muscle contraction [ISO]
- transition between fast and slow fiber [IDA]
- ventricular cardiac muscle tissue morphogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction.
Speckle-type pox virus and zinc finger (POZ) protein (SPOP), a substrate recognition adaptor of cullin-3 (CUL3)/RING-type E3 ligase complex, is investigated for its role in cardiac fibrosis in our study. Cardiac fibroblasts (CFs) activation was achieved with TGF-?1 (20 ng/mL) and MI mouse model was established by ligation of the left anterior descending coronary, and lentivirus was employed to mediate interference ... [more]
Cell Chem Biol Oct. 19, 2023; 30(10);1248-1260.e4 [Pubmed: 37442135]
Throughput
- High Throughput
Curated By
- BioGRID