BAIT
SPOP
AI315626, Pcif1, TEF2, RP23-67E18.3
speckle-type POZ protein
GO Process (7)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- glucose homeostasis [IGI]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IGI]
- positive regulation of type B pancreatic cell apoptotic process [IGI]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IGI, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PLCD1
AW212592, C79986
phospholipase C, delta 1
GO Process (11)
GO Function (10)
GO Component (7)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- angiogenesis [IGI]
- cytosolic calcium ion homeostasis [ISO]
- labyrinthine layer blood vessel development [IGI]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISO]
- positive regulation of inositol trisphosphate biosynthetic process [ISO]
- positive regulation of norepinephrine secretion [ISO]
- regulation of cell proliferation [IGI]
- regulation of phospholipase C activity [ISO]
- response to calcium ion [ISO]
- response to peptide hormone [ISO]
Gene Ontology Molecular Function- GTPase activating protein binding [ISO]
- calcium ion binding [ISO]
- phosphatidic acid binding [IDA]
- phosphatidylinositol phosphate binding [IDA]
- phosphatidylinositol phospholipase C activity [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [ISO]
- phosphatidylserine binding [IDA]
- phospholipase C activity [IDA]
- phospholipid binding [ISO]
- protein binding [IPI]
- GTPase activating protein binding [ISO]
- calcium ion binding [ISO]
- phosphatidic acid binding [IDA]
- phosphatidylinositol phosphate binding [IDA]
- phosphatidylinositol phospholipase C activity [ISO]
- phosphatidylinositol-4,5-bisphosphate binding [ISO]
- phosphatidylserine binding [IDA]
- phospholipase C activity [IDA]
- phospholipid binding [ISO]
- protein binding [IPI]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Substrate-dependent interaction of SPOP and RACK1 aggravates cardiac fibrosis following myocardial infarction.
Speckle-type pox virus and zinc finger (POZ) protein (SPOP), a substrate recognition adaptor of cullin-3 (CUL3)/RING-type E3 ligase complex, is investigated for its role in cardiac fibrosis in our study. Cardiac fibroblasts (CFs) activation was achieved with TGF-?1 (20 ng/mL) and MI mouse model was established by ligation of the left anterior descending coronary, and lentivirus was employed to mediate interference ... [more]
Cell Chem Biol Oct. 19, 2023; 30(10);1248-1260.e4 [Pubmed: 37442135]
Throughput
- High Throughput
Curated By
- BioGRID