BAIT
ERBB2
CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
erb-b2 receptor tyrosine kinase 2
GO Process (30)
GO Function (12)
GO Component (7)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- axon guidance [TAS]
- cell proliferation [TAS]
- cell surface receptor signaling pathway [IDA]
- enzyme linked receptor protein signaling pathway [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA, IGI, TAS]
- phosphatidylinositol 3-kinase signaling [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of Rho GTPase activity [ISS]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell growth [IMP]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase I promoter [IMP]
- positive regulation of transcription from RNA polymerase III promoter [IDA]
- positive regulation of translation [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of angiogenesis [NAS]
- regulation of microtubule-based process [IDA]
- signal transduction [IDA]
- signal transduction by phosphorylation [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA, TAS]
- wound healing [IDA]
Gene Ontology Molecular Function- ErbB-3 class receptor binding [TAS]
- RNA polymerase I core binding [IDA]
- growth factor binding [IDA]
- identical protein binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein heterodimerization activity [IDA, IPI]
- protein phosphatase binding [IPI]
- protein tyrosine kinase activity [IDA, IGI, TAS]
- transmembrane receptor protein tyrosine kinase activity [IDA]
- transmembrane signaling receptor activity [IDA]
- ErbB-3 class receptor binding [TAS]
- RNA polymerase I core binding [IDA]
- growth factor binding [IDA]
- identical protein binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein heterodimerization activity [IDA, IPI]
- protein phosphatase binding [IPI]
- protein tyrosine kinase activity [IDA, IGI, TAS]
- transmembrane receptor protein tyrosine kinase activity [IDA]
- transmembrane signaling receptor activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
LRP4
CLSS, LRP-4, LRP10, MEGF7, SOST2
low density lipoprotein receptor-related protein 4
GO Process (14)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- dendrite morphogenesis [ISS]
- extracellular matrix organization [TAS]
- kidney development [IDA]
- limb development [IDA]
- negative regulation of axonogenesis [ISS]
- negative regulation of canonical Wnt signaling pathway [IDA, IMP]
- negative regulation of ossification [IMP]
- positive regulation of presynaptic membrane organization [ISS]
- postsynaptic membrane assembly [ISS]
- presynaptic membrane assembly [ISS]
- protein heterotetramerization [ISS]
- skeletal muscle acetylcholine-gated channel clustering [ISS]
- synapse organization [ISS]
- synaptic growth at neuromuscular junction [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Extracellular proximal interaction profiling by cell surface-targeted TurboID reveals LDLR as a partner of liganded EGFR.
Plasma membrane proteins play pivotal roles in receiving and transducing signals from other cells and from the environment and are vital for cellular functionality. Enzyme-based, proximity-dependent approaches, such as biotin identification (BioID), combined with mass spectrometry have begun to illuminate the landscape of proximal protein interactions within intracellular compartments. To extend the potential of these approaches to study the extracellular ... [more]
Sci Signal Nov. 05, 2024; 17(861);eadl6164 [Pubmed: 39499777]
Throughput
- High Throughput
Additional Notes
- Extracellular TurboID (ecTurboID)
- High confidence interactions had a 1% BFDR and a minimum of two spectral counts.
Curated By
- BioGRID