BAIT

ASB11

ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY

LRAT

LCA14
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
GO Process (2)
GO Function (1)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly.

Chou MC, Wang YH, Chen FY, Kung CY, Wu KP, Kuo JC, Chan SJ, Cheng ML, Lin CY, Chou YC, Ho MC, Firestine S, Huang JR, Chen RH

Purinosomes serve as metabolons to enhance de novo purine synthesis (DNPS) efficiency through compartmentalizing DNPS enzymes during stressed conditions. However, the mechanism underpinning purinosome assembly and its pathophysiological functions remains elusive. Here, we show that K6-polyubiquitination of the DNPS enzyme phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthetase (PAICS) by cullin-5/ankyrin repeat and SOCS box containing 11 (Cul5/ASB11)-based ubiquitin ligase plays a driving ... [more]

Mol Cell Nov. 16, 2023; 83(22);4123-4140.e12 [Pubmed: 37848033]

Throughput

  • High Throughput

Curated By

  • BioGRID