BAIT

SLC15A4

PHT1, PTR4, FP12591
solute carrier family 15 (oligopeptide transporter), member 4
GO Process (2)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Homo sapiens
PREY

ITFG3

C16orf9, gs19
integrin alpha FG-GAP repeat containing 3
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9.

Heinz LX, Lee J, Kapoor U, Kartnig F, Sedlyarov V, Papakostas K, Cesar-Razquin A, Essletzbichler P, Goldmann U, Stefanovic A, Bigenzahn JW, Scorzoni S, Pizzagalli MD, Bensimon A, Mueller AC, King FJ, Li J, Girardi E, Mbow ML, Whitehurst CE, Rebsamen M, Superti-Furga G

Toll-like receptors (TLRs) have a crucial role in the recognition of pathogens and initiation of immune responses1-3. Here we show that a previously uncharacterized protein encoded by CXorf21-a gene that is associated with systemic lupus erythematosus4,5-interacts with the endolysosomal transporter SLC15A4, an essential but poorly understood component of the endolysosomal TLR machinery also linked to autoimmune disease4,6-9. Loss of this ... [more]

Nature May. 01, 2020; 581(7808);316-322 [Pubmed: 32433612]

Throughput

  • High Throughput

Additional Notes

  • High confidence interactors had a Significance Analysis of Interactome (SAINT) FDR of <1% and were not present in the Contaminant Repository for Affinity Purification (CRAPome) database (Score >1).

Curated By

  • BioGRID