BAIT
ATG5
APG5, APG5-LIKE, APG5L, ASP, hAPG5
autophagy related 5
GO Process (10)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- C-terminal protein lipidation [IBA]
- autophagic vacuole assembly [IBA, ISS]
- autophagy [ISS]
- cellular response to nitrogen starvation [IBA]
- innate immune response [TAS]
- mitochondrion degradation [IBA]
- negative regulation of type I interferon production [TAS]
- nucleophagy [IBA]
- post-translational protein modification [ISS]
- regulation of cilium assembly [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PPME1
PME-1, PP2593
protein phosphatase methylesterase 1
GO Process (3)
GO Function (5)
GO Component (0)
Gene Ontology Biological Process
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion.
ATG5 is a part of the E3 ligase directing lipidation of ATG8 proteins, a process central to membrane atg8ylation and canonical autophagy. Loss of Atg5 in myeloid cells causes early mortality in murine models of tuberculosis. This in vivo phenotype is specific to ATG5. Here, we show using human cell lines that absence of ATG5, but not of other ATGs directing ... [more]
Dev Cell May. 22, 2023; 58(10);866-884.e8 [Pubmed: 37054706]
Throughput
- High Throughput
Curated By
- BioGRID