RBCK1
Gene Ontology Biological Process
- T cell receptor signaling pathway [IDA]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein linear polyubiquitination [IDA]
- protein polyubiquitination [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AMOT
Gene Ontology Biological Process
- actin cytoskeleton organization [TAS]
- cell-cell junction assembly [TAS]
- cellular protein localization [IDA]
- hippo signaling [IGI, TAS]
- negative regulation of angiogenesis [IDA]
- negative regulation of vascular permeability [IDA]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of cell size [TAS]
- positive regulation of stress fiber assembly [TAS]
- regulation of cell migration [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Noncanonical regulation of HOIL-1 on cancer stemness and sorafenib resistance identifies pixantrone as a novel therapeutic agent for HCC.
Cancer stem cells (CSCs) contribute to therapy resistance in HCC. Linear ubiquitin chain assembly complex (LUBAC) has been reported to accelerate the progression of cancers, yet its role in the sorafenib response of HCC is poorly defined. Herein, we investigated the impact of LUBAC on sorafenib resistance and the CSC properties of HCC, and explored the potential targeted drugs.We found ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RBCK1 AMOT | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 2603671 |
Curated By
- BioGRID